This research intends to identify a feasible UHC model for Cambodia employing the ‘most similar system design’ as a comparative method by using Thailand and Rwanda as case studies. Catastrophic health spending, lack of financial health protection for the population, and a fragmented social health system persist as the main concerns to be addressed. In the case of Cambodia where primary data is accessible, semi-structured interviews and focus group discussions were conducted with key informants including local and international health organizations, government health agencies, and university clinical lecturers and students. The research found that the delivery of quality health services was the main constraint to UHC being achieved followed by fiscal limitations. The paper provides policy recommendations as a roadmap for Cambodia to achieve UHC with full population coverage, financial sustainability and the provision of quality healthcare services.